Tramadol Overdose, Tramadol Hydrochloride

Term over dosage comes to the picture when you consume extra dose of a particular prescription based short term usage medication. It is highly recommended not to consume prescription based medication like tramadol hydrochloride beyond prescribed time period as it may result in serious fatal side effects and addiction of this medication.  

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Serious potential consequences of overdosage of tramadol are mentioned below:

• Respiratory depression
• Lethargy
• Coma

Seizure

• Cardiac arrest and death.

Fatalities have been reported in post marketing in association with both intentional and unintentional overdose with tramadol. In treating an overdose, primary attention should be given to maintaining adequate ventilation along with general supportive treatment. While naloxone will reverse some, but not all, symptoms caused by overdosage with tramadol, the risk of seizures is also increased with naloxone administration.

In animals convulsions following the administration of toxic doses of tramadol could be suppressed with barbiturates or benzodiazepines but were increased with naloxone. Naloxone administration did not change the lethality of an overdose in mice. Hemodialysis is not expected to be helpful in an overdose because it removes less than 7% of the administered dose in a 4-hour dialysis period.

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